Amgen Senior Scientist - Statistical Geneticist (#R-74143) Cambridge, MA
The Translational Systems Biology Group within the Comparative Biology and Safety Sciences (CBSS) department at Amgen Cambridge is committed to bringing transformative medicines to patients. Our mission is to apply a variety of human-centric approaches to develop methodologies that can assess the safety of our drug targets or elucidate mechanisms leading to drug toxicity. We heavily use large scale human genetics data to identify risk factors contributing to drug safety and to guide the development of therapeutics programs. Building upon world-class expertise and experience in human genetics research brought by deCODE Genetics (an Amgen subsidiary), Amgen is expanding human genetics dedication with ground breaking collaboration with Intermountain Healthcare to genotype 500,000 people and with participation in UK Biobank project to whole genome sequence all 500,000 participants. In-depth analysis of genetic data will reveal potential links between genetic variations and disease risks, leading to innovative ways to understand, diagnose, treat and prevent life-changing illnesses. We are seeking a statistical geneticist to join our efforts in using complex, high-dimensional genetics datasets to support drug safety evaluation. The Senior Scientist will be a core contributor in our safety investigation of potential therapeutics or target interventions and play a hands-on role conducting integrated analyses combining large-scale genetics data and preclinical and clinical safety data.
Responsibilities: • Drive in silico efforts focused on integrating public and proprietary genetics and omics data resources for novel insights into target biology and drug safety • Provide quantitative genetics/genomics expertise and lead the design, execution, and interpretation of genetic studies to investigate the influence of genetic variants on drug response • Perform analyses using multiple data types (e.g. pre-clinical data, drug side-effects, genetic variation, pharmacology) to support Amgen predictive safety efforts • Define the strategy and goals for the application of human genetics/pharmacogenetics to drug safety assessment • Initiate, design and establish internal and external collaborations in the area of human genetics to inform target selection, safety assessment and de-risking • Serve as human genetics/computational biology lead interacting with Amgen toxicologists, lab scientists, statistician, bioinformatician, clinicians and project leaders to deliver critical safety evaluation and promote the science of human genetics for safety assessment • Mentor associates and postdoctoral fellows who lead genetic studies and projects, including wet lab molecular genetics experiments
Basic Qualifications: • Doctorate degree and 2 years of scientific experience OR • Master's degree and 5 years of scientific experience OR • Bachelor's degree and 7 years of scientific experience
Preferred Qualifications: • Ph.D. in Human Genetics, Genetics Epidemiology, Biostatistics, Bioinformatics with 3+ years of statistical genetics experience • Ability to design and lead human genetics studies (with a variety of study designs) delivering novel and actionable genetic findings relevant to drug development • Expertise with multiple molecular genetic techniques including chip-typing, WES & WGS, single-cell and bulk sequencing approaches, etc. • Familiarity with population genetics and deep knowledge of statistical modeling, machine learning and biological networks • Proficiency in computing languages and statistical software, statistical genetics tools and large-scale data platforms, and hands on experience in large scale genetics and ‘omics data analysis • Strong publication track record in top tier journals • Comfortable working in a highly interactive and vibrant environment with a team with varied strengths • Excellent leadership and communication skills and the ability to influence, inspire and lead the team into new scientific areas
Amgen is committed to unlocking the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing and delivering creative human therapeutics. This approach begins by using tools like advanced human genetics to unravel the complexities of disease and understand the fundamentals of human biology.
Amgen focuses on areas of high unmet medical need and leverages its expertise to strive for solutions that improve health outcomes and dramatically improve people's lives. A biotechnology pioneer since 1980, Amgen has grown to be one of the world's leading independent biotechnology companies, has reached millions of patients around the world and is developing a pipeline of medicines with breakaway potential.
Work alongside the best. Be part of our highly talented, hard-working teams. Their spirit is what fuels our success.
Amgen's outstanding compensation package features comprehensive benefits. To learn more about this opportunity and to apply, please visit us online at http://careers.amgen.com/ and search job #R-74143.
Our culture is what makes Amgen a special place to work. We have a powerful shared purpose around our mission - to serve patients. We respect one another, recognize contributions, and have embedded collaboration, trust, empowerment and inclusion in all that we do. Work alongside the best. Be part of our highly talented, hard-working teams. Their spirit is what fuels our success.
Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.