Postdoctoral Research Fellowship in Computational Genomics with a Focus on Circadian Biology
Lane Laboratory in the Division of Sleep and Circadian Disorders at Brigham and Women's Hospital
Location: Boston, Massachusetts
Type: Full Time
Required Education: Doctorate
Years of Experience:
5 - 10
2 openings available.
The Lane Laboratory in the Division of Sleep and Circadian Disorders at Brigham and Women's Hospital is looking for postdoctoral fellow(s) to work in the field of computational genomics and bioinformatics with a special interest in sleep and circadian biology as part of the Lane Lab. We strongly believe in the advancement of human health using genomics to answer questions about basic circadian biology and to improve human health in the clinic with teaching, mentoring, and learning for all in the laboratory as essential components of our research at Brigham and Women’s Hospital. We are excited to grow our collaborative and interdisciplinary research program marrying genetics with functional approaches to address important issues in human health related to sleep and circadian biology.
Circadian rhythms, our 24-hour internal biological clock, touch nearly all facets of human health. We are seeking postdoctoral fellows with skills in human genetics to interrogate the relationship between circadian rhythms and psychiatric disorders, to utilize electronic health records to learn about circadian rhythm disorders, and to apply machine learning to complex datasets derived from health datasets to create new diagnostic and treatment paradigms.
The Lane Lab has additional affiliations in the Center for Genomic Medicine at Massachusetts General Hospital and the Medical and Population Genetics Program at the Broad Institute of MIT and Harvard. We have many exciting collaborations, and all fellows will have regular meetings with senior co-mentor Richa Saxena. We have access to multiple large genomic study cohorts and computational infrastructure, including cloud platforms. We also have a wet lab, so our computational models/predictions can be validated in-house within the lab, and candidates who intend to pursue their own molecular work along with training in computational work are encouraged to apply. Details about the Lane laboratory can be found at https://scholar.harvard.edu/jacqueline-lane.
The Lane Lab values unique and diverse perspectives, kindness, hard work, and overall health of our team. We strive for our research group to be a place where all are welcome, valued, encouraged, and accepted. We believe that good science and good scientists are born from a diverse and inclusive workforce, and we recognize that diversity comes in many forms. The Lane Lab is actively engaged in efforts to increase diversity both in our lab and in our clinical trials, and we encourage applicants from under-represented backgrounds.
Interested applicants should send your CV and a brief statement of your research interests to firstname.lastname@example.org with “Lane Lab Postdoctoral Research Fellowship” in the subject line.
We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, gender identity, sexual orientation, pregnancy and pregnancy-related conditions or any other characteristic protected by law.
Ideal candidates will have a PhD in computational biology/genetics/computer science or other quantitative fields and satisfy at least one of the criteria below:
Prior experience in developing NGS analysis tools, performing integrative bioinformatics analysis, and/or studying population genetics/evolutionary biology
Strong mathematical/statistical background with high motivation to study biomedical research
Strong computer science/IT background with high motivation to study biomedical research.
About Lane Laboratory in the Division of Sleep and Circadian Disorders at Brigham and Women's Hospital
I strongly believe in the advancement of human health by using genomics to answer questions about basic biology and neuropsychiatric disease risk. I am excited to establish a successful collaborative and interdisciplinary research program marrying genetics with functional approaches to address important issues in human health related to sleep and circadian biology.
Circadian rhythms regulate human behavior and physiology within the 24hr day. Dysregulation of those rhythms are associated with sleep disorders, cognitive and physical performance, cancer, and chronic disease, however, little is known about the link between human circadian rhythms and health and physiology. We will identify novel genetic factors for circadian rhythms by sequencing extreme circadian rhythm disorder patients. For this purpose, we are assembling a new cohort study. Circadian rhythm disorders are inherited sleep disorders of the circadian system, which present as extremely shifted or irregular sleep timing and current treatments are limited, difficult to implement, and ineffective. Initial family-based genetic studies of circadian rhythm disorders implicated mutations in genes involved in the core molecu...lar circadian clock (PER2, PER3, CSNK1D). In our study, we will extend the interrogation of circadian rhythm disorder causative mutations beyond the few family-based studies by recruiting a new cohort of circadian disorder patients, with the hypothesis that patients with extreme circadian rhythm disorders harbor rare loss-of-function mutations in core components of the circadian clock. We will test this by establishing a novel at-home testing based extreme circadian disorder cohort and identifying new genes for circadian rhythm disorders by sequencing and analyzing the exome of circadian rhythm disorder patients.
Ultimately, this work will identify new causal genetic factors for circadian rhythm disorders and elucidate biological pathways underlying circadian regulation. These findings will benefit circadian disorder patients by allowing for the development of novel therapeutics for rare circadian rhythms disorders, increasing our understanding of the basic mechanisms of circadian biology in humans, and ultimately shedding light on how circadian rhythm dysregulation predisposes to associated chronic diseases.